Geavanceerde oxidatie van chinolon antibiotica door middel van ozon en het peroxonproces

In recent years, the fate of pharmaceuticals in the aquatic environment has become an emerging issue because of their threat for aquatic organisms and human health. Endocrine disruptingagents, for instance, can interfere with natural hormones, hydrophobic pharmaceuticals can accumulate in the environment, antibiotics can cause bacterial resistance, etc.

A lot of pharmaceuticals are hardly biodegradable. Their degradation in WWTPs is often incomplete. Concentrations up to several µg/l have been measured in surface waters. Fysico-chemical techniques such as advanced oxidation processes (AOPs) are necessary for their removal. When UV/H2O2, Fenton-reagents or ozonation are used, degradation or enhancement of biodegradability of persistent pharmaceuticals has been noticed. However, a lot of research is necessary to obtain a better insight in the use of AOPs for removal of pharmaceuticals. There is also a lack of information on the intermediates formed.

The aim of the research is to investigate the possibilities of several AOPs for the degradation of antibiotics and anti-neoplastics. Besides removal efficiencies, intermediates and degradation pathways will be investigated by making use of high resolution and multidimensional mass spectrometry.

   Van Langenhove, Herman promotor
   Dewulf, Jo promotor

    S.l. : s.n., 2010.

    X, 215 p.: ill.